Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. He loves hills that much he's almost over one...Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains. Prof. John McCarron likes mountains, and lies about mountains (it'll be fun he said), and likes going up mountains.
In his spare time, John likes going up mountains.
Endothelial cell ca wave propagation extent is increased in hypertension
En face preparations of 2nd and 3rd order rat mesenteric arteries were loaded up with the Ca indicator dye, Cal-520, and the photolabile form of IP , membrane-permeant caged-IP . Calcium signalling is triggered in an agonist-independent manner by applying spatially-restricted UV light to a chosen activation site. The Ca signal spreads radially from the uncaging site, producing an intercellular wave with a clearly defined origin. All subsequent Ca events outside the photolysis region result directly from the initial uncaging, reflecting true signal propagation. In this video, we show the difference in Ca wave propagation extent in normotensive (WKY, green) arteries compared to that of hypertensive (SHR, magenta) arteries. The extent of the caged IP -evoked Ca wave is significantly increased in arteries from hypertensive animals, compared to normotensive animals.
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