Microtubule depolymerization blocks cIP  -mediated Ca    wave propagation

En face mesenteric artery stained with Cal520/AM (5 µM, grey) and cIP  (5 μM). Ca   activity was stimulated by localized photolysis of cIP  (yellow circle) after a baseline recording (10 Hz). In the same preparation, the resulting Ca   activity is visualized in green before (control) and in the presence of the microtubule destabilizer Colchicine (250 µM, 30 mins). Scale bar: 50 μm.