Our group is interested in investigating the mechanisms by which the endothelium, the innermost layer of cells lining the entire vascular network, communicates with the underlying smooth muscle in order to modulate vascular function. This is of particular importance as this communication is disrupted in disease states like diabetes and hypertension.
In order to understand this communication, we needed to develop technologies that would allow us to image and manipulate cell signalling by the ubiquitous second messenger calcium at high spatial and temporal resolution. This has enables us to perform a wide range of pharmacological and mechanical experiments in both intact and en face arterial preparations to better understand the mechanisms behind vascular function.
Please click on the links below to read more about the work we do, and the technologies we have developed...