Dr Calum Wilson MEng, EngD
Sir Henry Wellcome Postdoctoral Research Fellow
Half engineer, half physiologist, half historian of the Byzantine empire, Calum is a Sir Henry Wellcome Research Fellow that never was any good at maths. Calum is interested in understanding how blood vessel function is regulated by mechanical forces. To help him do so he builds specialised microscopes and experimental apparatus, and writes custom analysis software. If he doesn't know how something works, he will disassemble it. Most of the time he will manage to put things back together properly. Calum's work has received several accolades. Notably, he is a two-time recipient of the Journal of Physiology Early Investigator Prize. More recently, Calum was invited to join the Editorial Board of the Journal of Physiology as an Editorial Fellow.
Everyone else provided details about what they get up to in their spare time, but Calum did not want to lie by pretending he had any.
Calum can be contacted via:
Zhang, X, Lee MD, Buckley C, Wilson, C, McCarron, JG, 2021, 'Mitochondria regulate TRPV4 mediated release of ATP'. British Journal of Pharmacology. DOI: 10.22541/au.161941863.34069176/v1 (Accepted)
Buckley, C, Zhang, X, Wilson, C, McCarron, JG, 2020, 'Carbenoxolone and 18b-glycyrrhetinic acid inhibit IP3-mediated endothelial cell calcium signalling and depolarise mitochondria'. British Journal of Pharmacology. DOI: 10.1111/bph.15329
Wilson, C, Zhang, X, Lee, MD, MacDonald, M, Heathcote, HR, Alorfi, NMN, Buckley, C, Dolan, S, McCarron, JG 2019, 'Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity'. Metabolism. DOI: 10.1016/j.metabol.2020.154340
Buckley, C, Wilson, C, McCarron, JG 2019, 'FK506 regulates IP3-evoked Ca2+ release independently of FKBP in endothelial cells'. British Journal of Pharmacology. DOI: 10.1111/bph.14905
Zhang, X, Lee, MD, Wilson, C, McCarron, JG 2019, 'Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries'. Cell Calcium. DOI: 10.1016/j.ceca.2019.102108
Lawton, PF, Buckley, C, Saunter CD, Wilson, C, Corbett AD, Salter PS, McCarron, JG, Girkin JM 2019, 'Multi-plane remote refocusing epifluorescence microscopy to image dynamic Ca2+ events'. Biomedical Optics Express. DOI: 10.1364/BOE.10.005611
Wilson, C, Zhang, X, Buckley, C, Heathcote, H, Lee, MD, McCarron, JG 2019, 'Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling' Hypertension. DOI: 10.1161/HYPERTENSIONAHA.119.13791
Heathcote, H, Lee, MD, Zhang, X, Wilson, C, McCarron, JG,(2019). Endothelial TRPV4 channels modulate vascular tone by Ca2+-induced Ca2+ release at IP3 receptors. British Journal of Pharmacology DOI: 10.1111/bph.14762
McCarron, JG, Wilson, C, Heathcote, H, Zhang, X, Buckley, C, and Lee, MD (2019). Heterogeneity and emergent behaviour in the vascular endothelium. Current Opinions in Pharmacology DOI: 10.1016/j.coph.2019.03.008
Lawton, PF, Lee, MD, Saunter, CD, Girkin, JM, McCarron, JG and Wilson, C (2019). VasoTracker, a low-cost and open source pressure myograph system for vascular physiology. Frontiers in Physiology DOI: 10.3389/fphys.2019.00099
Wilson, C, Lee, MD, Heathcote, H, Zhang, X, Buckley, C, Girkin, JM, Saunter, CD, McCarron, JG 2019, 'Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling' Journal of Biological Chemistry. DOI: 10.1074/jbc.RA118.005913
Lee, MD, Wilson, C, Saunter, CD, Kennedy, C, Girkin, JM, McCarron, JG, 2018, 'Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium' Science Signaling, vol 11, no. 9. DOI: 10.1126/scisignal.aar4411
McCarron, JG, Saunter, C, Wilson, C, Girkin, JM & Chalmers, S 2018, Mitochondria structure and position in the local control of calcium signals in smooth muscle cells. in M Trebak & S Earley (eds), Signal Transduction and Smooth Muscle.Boca Raton, Florida, pp. 173-190.
McCarron, JG, Lee, MD & Wilson, C 2017, 'The endothelium solves problems that endothelial cells do not know exist' Trends in Pharmacological Sciences, vol 38, no. 4, pp. 322-338. DOI: 10.1016/j.tips.2017.01.008
Wilson, C, Saunter, CD, Girkin, JM & McCarron, JG 2017, 'Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries' Journal of Vascular Research, vol 53, no. 5-6, pp. 358–369. DOI: 10.1159/000454811
Wilson, C, Lee, MD & McCarron, JG 2016, 'Acetylcholine released by endothelial cells facilitates flow-mediated dilatation' Journal of Physiology, vol 594, no. 24, pp. 7267-7307. DOI: 10.1113/JP272927
McCarron, J.G., Chalmers, S., Wilson, C. and Sandison, M.E., 2016. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle. In Vascular Ion Channels in Physiology and Disease (pp. 233-253). Springer, Cham.
Wilson, C., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2016. Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in the intact endothelium. The FASEB Journal, 30(5), pp.2000-2013.
Wilson, C., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2015. Pressure‐dependent regulation of Ca2+ signalling in the vascular endothelium. The Journal of physiology, 593(24), pp.5231-5253. DOI: 10.1113/JP271157
McCarron, J.G., Wilson, C., Sandison, M.E., Olson, M.L., Girkin, J.M., Saunter, C. and Chalmers, S., 2013. From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle. Journal of vascular research, 50(5), pp.357-371. DOI: 10.1159/000353883
McCarron, J.G., Olson, M.L., Wilson, C., Sandison, M.E. and Chalmers, S., 2013. Examining the role of mitochondria in Ca2+ signaling in native vascular smooth muscle. Microcirculation, 20(4), pp.317-329. DOI: 10.1111/micc.12039
Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J.M. and McCarron, J.G., 2012. Mitochondrial motility and vascular smooth muscle proliferation. Arteriosclerosis, thrombosis, and vascular biology, 32(12), pp.3000-3011.