Publications

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2024

Zhang, X, Buckley, C, Lee, MD, MacDonald, M, Wilson, C, McCarron, JG 2024, 'Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension'. Biorxiv. https://doi.org/10.1101/2024.03.27.587031

Buckley, C, Lee, MD, Zhang, X, Wilson, C, McCarron, JG 2024, 'Signalling switches maintain intercellular communication in the vascular endothelium'. British Journal of Pharmacology. https://doi.org/10.1111/bph.16366

2023

Zhang, X, Lee MD, Buckley, C, Hollenberg, MD, Wilson, C, McCarron, JG 2023, 'Endothelial PAR2 activation evokes resistance artery relaxation'. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.30973

Wilson, C, Lee MD, Buckley, C, Zhang, X, McCarron, JG 2022, 'Mitochondrial ATP production is required for endothelial cell control of vascular tone'. Function. https://doi.org/10.1093/function/zqac063

2022

Wilson, C, McCarron, JG, Lee MD, 2022, 'William Bayliss and the enduring fascination of myogenic tone'. The Journal of Physiology. DOI: 10.1113/JP282890

Lee MD, Buckley C, Zhang, X, Louhivuori, L, Uhlen, P, Wilson, C, McCarron, JG, 2022, 'Small-world connectivity dictates collective endothelial cell signaling'. PNAS. DOI: 10.1073/pnas.2118927119

McCarron, JG & Wilson, C, 2022, 'The selfish mitochondrion'. Cell Calcium. DOI: 10.1016/j.ceca.2021.102498.

Zhang, X, Lee MD, Buckley C, Wilson, C, McCarron, JG, 2022, 'Mitochondria regulate TRPV4 mediated release of ATP'. British Journal of Pharmacology. DOI: 10.1111/bph.15687

2021

Caldwell, ST, O'Byrne, SN, Wilson, C, Cvetko, F, Murphy, MP, McCarron, JG, Hartley, RC, 2021, 'Photoactivated release of membrane impermeant sulfonates inside cells'. Chem Commun. DOI: 10.1039/d0cc07713e

Buckley, C, Zhang, X, Wilson, C, McCarron, JG, 2021, 'Carbenoxolone and 18b-glycyrrhetinic acid inhibit IP3-mediated endothelial cell calcium signalling and depolarise mitochondria'. British Journal of Pharmacology. DOI: 10.1111/bph.15329

Ivy JR, Carter RN, Zhao JF, Buckley, C, ....., Chapman KE, 2021, 'Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes'. Journal of Physiology. DOI: http://doi.org/10.1113/JP281860

Buckley, C, 'Total internal reflection fluorescence microscopy'. Imaging Modalities for Biological and Preclinical Research: A compendium, Volume 1, IoP Science, Pages 1.3a-1 to 1.3.a-9

Zhang, X, Alhasani, R, Shu, X, Reilly, J, Zeng, Z, Strang, N, 2021, 'Oxysterols and retinal degeneration'. British Journal of Pharmacology.

DOI: 10.1111/bph.15391

2020

Kaveh, A, Bruton, FA, Buckley, C, Oremek, M, Tucker, CS, Mullins, JJ, Taylor, JM, Rossi, AG, Denvir, MA, 2020, 'Live imaging of heart injury in larval zebrafish reveals a multi-stage model of neutrophils and macrophage migration'. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2020.579943

Wilson, C, Zhang, X, Lee, MD, MacDonald, M, Heathcote, HR, Alorfi, NMN, Buckley, C, Dolan, S, McCarron, JG 2019, 'Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity'. Metabolism. DOI: 10.1016/j.metabol.2020.154340

2019

Buckley, C, Wilson, C, McCarron, JG 2019, 'FK506 regulates IP3-evoked Ca2+ release independently of FKBP in endothelial cells'. British Journal of Pharmacology. DOI: 10.1111/bph.14905

Zhang, X, Lee, MD, Wilson, C, McCarron, JG 2019, 'Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries'. Cell Calcium. DOI: 10.1016/j.ceca.2019.102108

Lawton, PF, Buckley, C, Saunter CD, Wilson, C, Corbett AD, Salter PS, McCarron, JG, Girkin JM 2019, 'Multi-plane remote refocusing epifluorescence microscopy to image dynamic Ca2+ events'. Biomedical Optics Express. DOI: 10.1364/BOE.10.005611

Wilson, C, Zhang, X, Buckley, C, Heathcote, HR, Lee, MD, McCarron, JG 2019, 'Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling' Hypertension. DOI: 10.1161/HYPERTENSIONAHA.119.13791

Heathcote, HR, Lee, MD, Zhang, X, Wilson, C, McCarron, JG,(2019). Endothelial TRPV4 channels modulate vascular tone by Ca2+-induced Ca2+ release at IP3 receptors. British Journal of Pharmacology DOI: 10.1111/bph.14762

McCarron, JG, Wilson, C, Heathcote, HR, Zhang, X, Buckley, C, and Lee, MD (2019). Heterogeneity and emergent behaviour in the vascular endothelium. Current Opinions in Pharmacology DOI: 10.1016/j.coph.2019.03.008

Lawton, PF, Lee, MD, Saunter, CD, Girkin, JM, McCarron, JG and Wilson, C (2019). VasoTracker, a low-cost and open source pressure myograph system for vascular physiology. Frontiers in Physiology DOI: 10.3389/fphys.2019.00099

Wilson, C, Lee, MD, Heathcote, HR, Zhang, X, Buckley, C, Girkin, JM, Saunter, CD, McCarron, JG 2019, 'Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling' Journal of Biological Chemistry. DOI: 10.1074/jbc.RA118.005913

2018

Lee, MD, Wilson, C, Saunter, CD, Kennedy, C, Girkin, JM, McCarron, JG, 2018, 'Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium' Science Signaling, vol 11, no. 9. DOI: 10.1126/scisignal.aar4411

McCarron, JG, Saunter, C, Wilson, C, Girkin, JM & Chalmers, S 2018, Mitochondria structure and position in the local control of calcium signals in smooth muscle cells. in M Trebak & S Earley (eds), Signal Transduction and Smooth Muscle.Boca Raton, Florida, pp. 173-190.

Patnaik, SR, Zhang, X, Biswas, L, Akhtar, S, Zhou, X, Kusuluri, DK, Reilly, J, May-Simera, H, Chalmers, S, McCarron, JG & Shu, X 2018, 'RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry' Oncotarget, vol 9, no. 33, pp. 23183-23197. DOI: 10.18632/oncotarget.25259

2017

McCarron, JG, Lee, MD & Wilson, C 2017, 'The endothelium solves problems that endothelial cells do not know exist' Trends in Pharmacological Sciences, vol 38, no. 4, pp. 322-338. DOI: 10.1016/j.tips.2017.01.008

Wilson, C, Saunter, CD, Girkin, JM & McCarron, JG 2017, 'Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries' Journal of Vascular Research, vol 53, no. 5-6, pp. 358–369. DOI: 10.1159/000454811

2016

Wilson, C, Lee, MD & McCarron, JG 2016, 'Acetylcholine released by endothelial cells facilitates flow-mediated dilatation' Journal of Physiology, vol 594, no. 24, pp. 7267-7307. DOI: 10.1113/JP272927

Sandison, ME, Dempster, J & McCarron, JG 2016, 'The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation' Journal of Physiology, vol 594, no. 21, pp. 6189-6209. DOI: 10.1113/JP272729

Chalmers, S., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2016. Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle. The Journal of physiology, 594(15), pp.4283-4295. DOI: 10.1113/JP271942

McCarron, J.G., Chalmers, S., Wilson, C. and Sandison, M.E., 2016. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle. In Vascular Ion Channels in Physiology and Disease (pp. 233-253). Springer, Cham.

Wilson, C., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2016. Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in the intact endothelium. The FASEB Journal, 30(5), pp.2000-2013. DOI: 10.1096/fj.201500090

2015

Caldwell, S.T., Cairns, A.G., Olson, M., Chalmers, S., Sandison, M., Mullen, W., McCarron, J.G. and Hartley, R.C., 2015. Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp.9571-9578. DOI: 10.1016/j.tet.2015.10.052

Wilson, C., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2015. Pressure‐dependent regulation of Ca2+ signalling in the vascular endothelium. The Journal of physiology, 593(24), pp.5231-5253. DOI: 10.1113/JP271157

Chalmers, S., Saunter, C.D., Girkin, J.M. and McCarron, J.G., 2015. Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension. Scientific reports, 5, p.16875. DOI: 10.1038/srep16875

Sandison, M. and McCarron, J., 2015. Heterogeneity in the Proliferative Capacity of Smooth Muscle Cells (SMCs). The FASEB Journal, 29(1_supplement), pp.418-8.

2014

Sandison, M., Chalmers, S., Dempster, J. and McCarron, J., 2014. Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging (867.12). The FASEB Journal, 28(1_supplement), pp.867-12.

2013

McCarron, J.G., Wilson, C., Sandison, M.E., Olson, M.L., Girkin, J.M., Saunter, C. and Chalmers, S., 2013. From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle. Journal of vascular research, 50(5), pp.357-371. DOI: 10.1159/000353883

McCarron, J.G., Olson, M.L., Wilson, C., Sandison, M.E. and Chalmers, S., 2013. Examining the role of mitochondria in Ca2+ signaling in native vascular smooth muscle. Microcirculation, 20(4), pp.317-329. DOI: 10.1111/micc.12039

Single cell and subcellular measurements of intracellular Ca2+ concentration

McCarron, J.G., Olson, M. L., Chalmers, S. & Girkin, J. M. 2013 Calcium Signaling Protocols. Lambert, D. G. & Rainbow, R. D. (eds.). Vol. 937, p. 239-251 13 p. (Methods in Molecular Biology; vol. 937)

2012

Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J.M. and McCarron, J.G., 2012. Mitochondrial motility and vascular smooth muscle proliferation. Arteriosclerosis, thrombosis, and vascular biology, 32(12), pp.3000-3011. DOI: 10.1161/ATVBAHA.112.255174

Olson, M.L., Sandison, M.E., Chalmers, S. and McCarron, J.G., 2012. Microdomains of muscarinic acetylcholine and InsP3 receptors create InsP3 junctions and sites of Ca2+ wave initiation in smooth muscle. J Cell Sci, pp.jcs-105163. DOI: 10.1242/jcs.105163

MacMillan, D, Kennedy, C & McCarron, J 2012, 'ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors' Journal of Cell Science, vol 125, no. 21, pp. 5151-5158. DOI: 10.1242/jcs.108498

McCarron, J, Chalmers, S, Olson, M & Girkin, J 2012, 'Subplasma membrane Ca2+ signals' IUBMB Life, vol 64, no. 7, pp. 573-585. DOI: 10.1002/iub.1032

Olson, ML, Chalmers, S & McCarron, JG 2012, 'Mitochondrial organization and Ca2+ uptake' Biochemical Society Transactions, vol 40, no. 1, pp. 158-167. DOI: 10.1042/BST20110705

McCarron, J, Olson, M & Chalmers, S 2012, 'Mitochondrial regulation of cytosolic Ca2+ signals in smooth muscle' Pflügers Archiv European Journal of Physiology , vol 464, no. special issue, pp. 51-62. DOI: 10.1007/s00424-012-1108-9

Chalmers, S, Caldwell, ST, Quin, C, Prime, TA, James, AM, Cairns, A, Murphy, MP, McCarron, J & Hartley, RC 2012, 'Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore' Journal of the American Chemical Society , vol 134, no. 2, pp. 758-761. DOI: 10.1021/ja2077922

For information about publications prior to 2012, please refer to PubMed