Dr Matthew D. Lee BSc, MRes
Post Doctoral Research Associate
Matt initially became interested in a research career in the final year of his Pharmacology degree at the University of Glasgow while undertaking an in vivo research project looking at the role of sphingosine-1-phosphate in the regulation of blood pressure. Following graduation, he undertook a MRes in Pharmacology at the University of Strathclyde, where he was fortunate enough to conduct a research project under the mentorship of Prof. John McCarron. After completion of his MRes Matt remained within the group undertaking a PhD supervised by Prof. McCarron and Dr Calum Wilson.
His PhD research involved using different experimental techniques to study both the sensory and functional aspects of the endothelium of conduit and resistance vessels with a particular interest in how the endothelium, a single layer of cells that lines the entire vasculature, can control a multitude of different physiological processes. Predominantly, this involves studying calcium signals evoked by different agonists using state of the art imaging systems and unique analysis software. By studying calcium signals in intact blood vessels Matt has been able to observe how the endothelium senses a host of different activators and by utilising pressure myography he has been able to study the functional effects of these different activators.
One of Matts recent accomplishments has been to help develop a new cost effective pressure myograph system called VasoTracker, helping to develop both the hardware and software, and in doing so has learnt programming in Python.
In his spare time Matt is a keen footballer, refereeing most weekends and golfing whenever he can. Matt spends as much time as he can travelling and visiting new places, including a recent trip across America, driving Route 66.
Contact Matt via:
Wilson, C, Zhang, X, Lee, MD, MacDonald, M, Heathcote, HR, Alorfi, NMN, Buckley, C, Dolan, S, McCarron, JG 2019, 'Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity'. Metabolism. DOI: 10.1016/j.metabol.2020.154340
Zhang, X, Lee, MD, Wilson, C, McCarron, JG 2019, 'Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries'. Cell Calcium. DOI: 10.1016/j.ceca.2019.102108
Wilson, C, Zhang, X, Buckley, C, Heathcote, H, Lee, MD, McCarron, JG 2019, 'Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling' Hypertension. DOI: 10.1161/HYPERTENSIONAHA.119.13791
Heathcote, H, Lee, MD, Zhang, X, Wilson, C, McCarron, JG,(2019). Endothelial TRPV4 channels modulate vascular tone by Ca2+-induced Ca2+ release at IP3 receptors. British Journal of Pharmacology DOI: 10.1111/bph.14762
McCarron, JG, Wilson, C, Heathcote, H, Zhang, X, Buckley, C, and Lee, MD (2019). Heterogeneity and emergent behaviour in the vascular endothelium. Current Opinions in Pharmacology DOI: 10.1016/j.coph.2019.03.008
Lawton, PF, Lee, MD, Saunter, CD, Girkin, JM, McCarron, JG and Wilson, C (2019). VasoTracker, a low-cost and open source pressure myograph system for vascular physiology. Frontiers in Physiology DOI: 10.3389/fphys.2019.00099
Wilson, C, Lee, MD, Heathcote, H, Zhang, X, Buckley, C, Girkin, JM, Saunter, CD, McCarron, JG 2019, 'Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling' Journal of Biological Chemistry. DOI: 10.1074/jbc.RA118.005913
Lee, MD, Wilson, C, Saunter, CD, Kennedy, C, Girkin, JM, McCarron, JG, 2018, 'Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium' Science Signaling, vol 11, no. 9. DOI: 10.1126/scisignal.aar4411
McCarron, JG, Lee, MD & Wilson, C 2017, 'The endothelium solves problems that endothelial cells do not know exist' Trends in Pharmacological Sciences, vol 38, no. 4, pp. 322-338. DOI: 10.1016/j.tips.2017.01.008
Wilson, C, Lee, MD & McCarron, JG 2016, 'Acetylcholine released by endothelial cells facilitates flow-mediated dilatation' Journal of Physiology, vol 594, no. 24, pp. 7267-7307. DOI: 10.1113/JP272927